Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans.Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely compared wild-t
Methylammonium Silicon Iodide (MASiI3), a novel perovskite material, has recently garnered significant attention for its potential to enhance the stability of solar cells.However, MASiI3-based perovskite solar cells (PSCs) have yet to achieve high performance.In this study, we utilized SCAPS-1D device modeling to investigate and optimize the perfor
Abstract Background Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive.In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and re
To determine the presence of sexual dimorphic transcription and how in vitro culture environments influence X-linked gene transcription patterns in preimplantation embryos, we analyzed mRNA expression levels in in vivo-derived, in vitro-fertilized (IVF), and cloned porcine blastocysts.Our results clearly show that sex-biased expression occurred bet
Abstract: Purpose: The train dispatching is a crucial issue in the train operation adjustment when passenger Olive Leaf flow outbursts.During holidays, the train dispatching is to meet passenger demand to the greatest extent, and ensure safety, speediness and punctuality of the train operation.In this paper, a fuzzy passenger demand forecasting mod